Postdoc in Innovative Microscopy to Probe the Biophysics of DNA replication

Research / Academic

We are seeking an exceptional experimentalist for a challenging and innovative project to design and construct a cutting-edge microscope for single-molecule studies of DNA replication. This project, which is funded by NWO, is a collaborative effort between experts in innovative microscopy and biophysics.
What are you going to do?
In this fully-funded 3-year project, you will:

  • be embedded in a communicative interdisciplinary team that is formed by a collaboration between two research groups at TU Delft;
  • build on our experience with optical design and single-molecule instrumentation to design and build a novel microscope combining imaging and force spectroscopy (magnetic tweezers);
  • develop/apply simulations and data analysis routines to predict and verify instrument functionality;
  • have the opportunity to obtain teaching experience and improve your leadership skills while guiding students;

About the project
Our goal is to develop and build a state-of-the-art microscope that will enable us to study the dynamics of DNA replication at the single-molecule level. The primary focus of the position is on building and testing the microscope, which will be used to study the activity of eukaryotic replisome.
As part of this project, you will be responsible for designing, constructing, and testing the novel microscope. You will also work on verifying samples using biophysical and biochemical technologies and analyzing datasets using biophysical modeling. Additionally, you will collaborate with international experts in the field, publish high-quality scientific papers, and make significant contributions to advancing this exciting area of research.
The Carlas Smith Lab (, internationally recognized for the development of next-generation imaging systems, is located within the Department of Delft Center for Systems and Control (DCSC) at the TU Delft. The lab develops next-generation imaging systems by synergistically combining novel hardware and information processing algorithms to achieve unprecedented performance. Here at the convergence of artificial intelligence, optics, mechatronics, and electronics, our diverse and interdisciplinary team at DCSC comprises passionate students and postdocs who strive to transcend the boundaries of imaging and actuation technologies by making the invisible visible.


For this innovative, interdisciplinary, and NWO-funded 3-year project, we are looking for an enthusiastic postdoc, with:

  • a completed Ph.D. degree in (bio)physics, quantitative microscopy, interdisciplinary nanosciences, biochemistry, or related areas;
  • practical experience in the above areas and single-molecule experiments and analysis are desired;
  • a strong motivation to develop either a quantitative microscopy skillset (optics and microscopy, advanced data analysis and pattern recognition) and interest in interdisciplinary research;
  • an independent, well-organized, and reliable work style together with an ability and interest in working in a small team;
  • good interpersonal communication skills and a strong interest in the broader field of biophysics, thereby contributing to our interactive lab culture.

We look for a friendly and driven colleague of all kinds to enrich our team. We would like to welcome the new postdoc as soon as possible.

Salary Benefits:

Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities (salary indication € 4.036 - € 5.090 per month gross). The TU Delft offers a customisable compensation package, discounts on health insurance, and a monthly work costs contribution. Flexible work schedules can be arranged.
For international applicants, TU Delft has the Coming to Delft Service. This service provides information for new international employees to help you prepare the relocation and to settle in the Netherlands. The Coming to Delft Service offers a Dual Career Programme for partners and they organise events to expand your (social) network.
This position is a temporary assignment for 36 months.

Work Hours:

36 - 40 hours per week


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