PhD Candidate: Cell-state Heterogeneity and Drug-responses in Cancer

Are you a team-oriented PhD candidate with an interest in molecular developmental biology and single-cell genomics? Would you like to learn and work in a multidisciplinary team in an innovative laboratory environment? If so, come and Join the lively and world-class RIMLS-Science Institute and work towards understanding the mechanisms driving cellular behaviour.

We are looking for a PhD candidate to join our team to study the influence of cell-state heterogeneity to drug responses in cancer, with the aim to develop strategies to rationally control cell behaviour to achieve better therapeutic efficacy. This is a collaborative project between Radboud University in Nijmegen and the Vrije Universiteit (VU) and Netherlands Cancer Institute (NKI) in Amsterdam, and is funded by the Dutch Cancer Society. State-of-the-art single-cell multi-omics techniques (Radboud) and computational modelling (VU/NCI) will be used to map and understand cellular responses to drugs over time. Our team members generally perform both experimental and computational work as part of their training. As a member of the RIMLS-Science institute and Department of Molecular Developmental Biology, you will enter our four-year PhD programme at Radboud University. You will be able to develop your teaching skills by providing internship supervision, tutorials and (optionally) lectures as 10% of your position will be dedicated to teaching.

Requirements:

• You should hold a Master's degree in Molecular or Cellular Biology, Biomedical Sciences, Molecular Life Sciences, or a related field.
• You have experience in one or several of the following areas: cell culture, single-cell genomics techniques and next-generation sequencing.
• You have experience in, or affinity with, computational analysis of (single-cell) genomics data.
• You possess strong analytical skills and a problem-solving, result-oriented attitude.
• You are a highly communicative and team science-minded professional. You have a good command of the English language (both verbal and written).

Salary Benefits:

• It concerns an employment for 0.8 (5 year contract) - 1.0 (4 year contract) FTE.
• The gross starting salary amounts to €2,770 per month based on a 38-hour working week, and will increase to €3,539 from the fourth year onwards (salary scale P).
• You will receive 8% holiday allowance and 8.3% end-of-year bonus.
• You will be employed for an initial period of 18 months, after which your performance will be evaluated. If the evaluation is positive, the contract will be extended by 2.5 years (4 year contract) or 3.5 years (5 year contract).
• You will be able to use our Dual Career and Family Care Services. Our Dual Career and Family Care Officer can assist you with family-related support, help your partner or spouse prepare for the local labour market, provide customized support in their search for employment and help your family settle in Nijmegen.
• Working for us means getting extra days off. In case of full-time employment, you can choose between 30 or 41 days of annual leave instead of the legally allotted 20.

Work and science require good employment practices. This is reflected in Radboud University's primary and secondary employment conditions. You can make arrangements for the best possible work-life balance with flexible working hours, various leave arrangements and working from home. You are also able to compose part of your employment conditions yourself, for example, exchange income for extra leave days and receive a reimbursement for your sports subscription. And of course, we offer a good pension plan. You are given plenty of room and responsibility to develop your talents and realise your ambitions. Therefore, we provide various training and development schemes.

40 hours per week

Houtlaan 4