PhD candidate for the project Chromatin-inspired supramolecular materials for biomedical application (1.0 fte)

Research / Academic


Project descrition

Nucleic acids are well-defined nanoscale building blocks that are programmable, responsive and addressable. Their application in the supramolecular polymer field is understudied despite the potential to endow these materials with orthogonally responsive character, which is highly desired for numerous applications in the biomedical area. In this project we will use DNA and chromatin proteins to generate supramolecular polymer networks that form hydrogels for applications in drug delivery. Specifically, we will employ protein-based DNA-DNA cross-linkers to fine-tune the properties of the hybrid DNA-based networks by modulating the density and strength of DNA-DNA cross-links.


  • Master’s degree in (Bio)Chemistry, Biophysics or equivalent;
  • Good to excellent command of English;
  • Ability to work independently in a multidisciplinary environment;
  • Required experience: Protein expression and purification, organic synthesis of small molecules and their characterization;
  • Experience with the characterization of soft materials is a plus;
  • The PhD research needs to start before December 2018.

Salary Benefits:

We offer a position for initially one year. After a positive evaluation of the progress of the thesis, personal capabilities and compatibility the appointment will be extended by a further three years. Salary range from €2,266 to €2,897 gross per month (pay scale P in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. For international spouses we have set up a dual career programme. Candidates from outside the Netherlands may be eligible for a substantial tax break. More at

All our PhD students are embedded in the Leiden University Graduate School of Science. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness. In addition, advanced courses to deepen scientific knowledge are offered by the research school.

Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

Work Hours:

38 hours per week


Einsteinweg 55