PhD on Proton Therapy

Research / Academic

In the ProtonBubbles project (NWO/NWA project, see we will develop a system for real-time localization and dosimetry during proton beam treatment. We will use microbubbles to convert the proton energy into an acoustic ultrasound signal and develop a very sensitive tuned opto-acoustical sensor to detect this signal. The final system can instantly show the exact position and dose of the proton-beam in a 3D clinical ultrasound image of the treated organ.

Conventional x-ray therapy is a basic pillar in cancer treatment, but has as a drawback collateral damage of healthy surrounding tissues. This is unavoidable due to the wide x-ray deposition range. A novel treatment uses protons, which are deposited in a well defined position. Unfortunately, patient movement and erroneous assumptions on tissue properties lead to differences between the treatment and planned locations. This may lead to partial tumour treatment and healthy tissue irradiation. Our solution detects the proton deposition location in real-time. The approach uses the interaction of protons and ultrasonic contrast agents combined with ultra-senstive opto-acoustic sensors. The project is a close cooperation between TNO and TU Delft in the fields of optics and acoustics and the Holland Proton Therapy Center, providing a unique basis for this groundbreaking work.


We are looking for a highly capable researcher with a Master degree in Biomedical Engineering, Applied Physics or similar. Expertise in MEMs, and/or optics and/or acoustics is essential and affinity with medical devices is desirable. The candidate should be fond of simulation and experimental work and enjoy multidisciplinar projets. Our candidate is highly motivated, adventurous and creative. Our candidate has an excellent command of the English language, and excellent  communication and team working skills. We expect the candidate to keep good contact with TNO and other collaborating companies. The research will be performed at the AWI group (TU Delft) and at the optics department of TNO.

Salary Benefits:

TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers childcare and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.
As a PhD candidate you will be enrolled in the TU Delft Graduate School. TU Delft Graduate School provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit for more information.

Work Hours:

32 - 38 hours per week


Lorentzweg 1