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PhD in Regulation of Mechanical Homeostasis of Cells and Tissues

Research / Academic
Eindhoven

Description:

The Eindhoven University of Technology (TU/e) is seeking an ambitious PhD candidate to investigate the mechanical homeostasis of cells and tissues during the progression of cardiovascular pathologies affecting cell and tissue mechanics. Research carried out by the successful candidate will be part of greater and exciting efforts aiming at establishing a new Platform for the Live Quantification of Cell and Tissue Mechanics at the TU/e.

Eindhoven University of Technology

TU/e is a University of Technology with a focus on Health, Energy and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, and Biosensing, with close links to healthcare and industry. TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.

Biomedical Engineering

The Department of Biomedical Engineering (BME) offers a research driven BME Bachelor program and Masters in Biomedical Engineering and Medical Engineering in its Graduate Program. Its research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modelling. The department has more than 800 students and up to 200 tenured and non-tenured employees.

Job description

The candidate will generate unprecedented experimental data to understand the physical basis of cardiovascular diseases affecting the mechanical homeostasis of cells and tissues. Investigations will aim at understanding how mechanical homeostasis is altered by disease progression as well as to determine how cell and tissue mechanics can be utilized to restore normal mechanical homeostasis in these pathological conditions. The in vitro experimental methods involved in this inquiry may include: i) Cell Traction Microscopy, Laser Ablation and Advanced Image Analyses for the quantification of cell and tissue mechanics; and, ii) Molecular and Cell Biology techniques for the manipulation of cellular genotype and phenotype. The candidate will build on established experimental protocols in order to further develop new methodological approaches for the handling of novel experimental setups currently unavailable in the field.

The PhD candidate is expected to do scientific research in the field described above, write a doctoral thesis and publish research results in scientific journals. An educational and professional development program is offered to all PhD candidates. A small part of the position involves teaching in courses offered by the group.

Requirements:

We are accepting applications from enthusiastic and highly talented candidates who are interested in a dynamic, stimulating and ambitious environment to perform their research. We are looking for candidates that meet the following requirements:
  • The candidate should have a background in Bioengineering, or Biotechnology, or Biophysics, or Biology or equivalent. Previous experience with microscopy techniques or microfabrication or primary/stem cell culture and manipulation as well as competencies in computer-based quantification/analysis (Matlab or similar) will be considered as a relevant added values.
  • The candidate should be able to effectively communicate scientific ideas, foster collaborations and have a capability for independent thinking.
  • Moreover, the candidate should be able to work independently within a dynamic team and be proficient in written and spoken English.
    The position will be based at the Eindhoven University of Technology (TU/e) in the Netherlands. TU/e has a strategic focus on Health, Energy and Mobility. Within the Health area, several departments collaborate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, and Biosensing, with close links to healthcare and industry.
    The research will be mainly conducted within the Soft Tissue Engineering and Mechanobiology (STEM) group in the Department of Biomedical Engineering under the supervision of Dr Vito Conte and prof.dr. C.V.C. Bouten, who heads the STEM group. prof.dr. C.V.C. Bouten's STEM group concentrates on the study of disease progression as well as on the engineering of soft tissues, which are aimed at either the replacement of diseased or malformed tissues, or the development of in-vitro model systems of developing tissues. Results are used to conceive possible anti-cancer mechano-therapies as well as to design novel approaches of in situ tissue regeneration with principal application in the cardiovascular area (heart valves and vessels) and organ regeneration (heart, cornea, and kidney). The group houses the Cell and Tissue Engineering laboratory, a shared research infrastructure operating at the international forefront of the engineering of living, load-bearing tissues.
  • Salary Benefits:

    We offer
  • A challenging job at a dynamic and ambitious University and in an enthusiastic team.
  • The appointment will be on a full-time basis for a period of four years with a yearly evaluation.
  • Support with your personal development and career planning including courses by offering every PhD student a series of courses in the PROOF program as an addition to your scientific education.
  • Gross monthly salaries are in accordance with the Collective Labour Agreement of the Dutch Universities (CAO NU), increasing from € 2.325,= per month initially, to € 2.972,= in the fourth year.
  • An attractive package of fringe benefits, including excellent work facilities, support in moving expenses and commuting expenses, pension scheme, extra holiday allowance 8% in May, end-of-year bonus of 8.3% in December and excellent sports facilities.
  • Work Hours:

    38 hours per week

    Address:

    De Rondom 70